The USAID Southern Africa Trade and Investment Hub continues to support 27 regional companies to produce personal protective equipment (PPE) and export it to South Africa and the United States. The companies taking part in the USAID TradeHub-supported effort are located in Botswana, Eswatini, Lesotho, and South Africa. As efforts to link regional producers with buyers in the U.S. market continue to advance, five companies have been prioritized for Food and Drug Administration registration and market linkage referrals. These are companies that are ready to begin production as soon as they secure an order, have experience exporting to the United States, and require no additional financing before they can fulfill an order. A U.S.-based marketing agency, Bhavana World, has also begun profiling the USAID TradeHub partner companies to present them to potential buyers. In addition to facilitating the connection with Bhavana World, the USAID TradeHub has leveraged its existing relationships with producers throughout the region to identify the participating companies. The effort, which aligns with the USAID TradeHub’s objectives to boost exports to South Africa and the United States, is also an example of the program’s response to the ongoing coronavirus pandemic.